Pt(II) complexes immobilized on polymer-modified magnetic carbon nanotubes as a new platinum drug delivery system

چکیده مقاله

We combine nanotechnology and chemical synthesis to create a novel multifunctional platinum drug delivery vehicle based on magnetic carbon nanotubes (multiwall carbon nanotubes/Fe₃O₄@poly(citric acid)/cis-[(Pt(1,7-phenanthroline)(DMSO)Cl₂)]-b-poly(ethylene glycol) (MCNTs/FO@PC/Pt(II)-b-PEG)) for targeted cancer therapy. MCNTs/FO@PC/Pt(II)-b-PEG was conveniently prepared by conjugating cis-[Pt(1,7-phenanthroline)(DMSO)Cl₂] complex to MCNTs/FO@PC-b-PEG via strong hydrogen-bonding interactions. In comparison with free cisplatin and Pt(II) complex, MCNTs/FO@PC/Pt(II)-b-PEG shows higher solubility in aqueous solution and higher cytotoxicity towards human cervical cancer HeLa cells and human breast cancer MDA-MB-231 cells. In vitro release experiments revealed that the platinum drug-loaded delivery system is relatively stable under physiological conditions (pH = 7.4 and 37 °C) but susceptible to acidic environments (pH = 5.6 and 37 °C) which would trigger the release of loaded drugs. Fluorescence microscopy studies revealed that this magnetic nanohybrid system possesses marked cell-specific targeting in vitro in the presence of an external magnetic field. The results indicated that the prepared superparamagnetic MCNTs/FO@PC/Pt(II)-b-PEG nanohybrid system is a promising candidate for inhibiting the proliferation of cancer cells. Copyright © 2018 John Wiley & Sons, Ltd.