Synthesis, cytotoxicity, and antioxidant activity by in vitro and molecular docking studies of an asymmetrical diamine containing piperazine moiety and related Zn(II), Cd(II) and Mn(II) macrocyclic schif base complexes

چکیده مقاله

Three new Zn(II), Cd(II) and Mn(II) macrocyclic Schiff base complexes have been prepared via the Mn(II), Cd(II), and Zn(II) templated [1 + 1] cyclo condensation of phtalaldehyde with an asymmetrical diamine, 2-((4-(2-((2-amino benzyl)amino)ethyl)piperazine-1-yl)methyl)aniline. The complexes have been characterized by elemental analysis, IR, ESI-MS, and NMR spectroscopy. The cytotoxicity of the compounds was evaluated against three different cancer cell lines, including MCF-7 (breast), A549 (lung), and AGS (gastric) adenocarcinoma cells. In general, Cd-complex possesses a higher cytotoxic effect against the tested cells than the Zn, and Mn_-complexes. Besides, antioxidant activity assays displayed that Cd, and Zn complexes had significant antioxidant potencies compared to ascorbic acid and quercetin, due to the standards. In addition, the biological assessment of synthesized complexes was examined via molecular docking. Findings showed that the Cd-complexes have the highest inhibition effect against cytotoxic and antioxidant receptors. © 2021 Elsevier B.V.