(N-isocyanimino)triphenylphosphorane as an efficient reagent for the preparation of N-benzyl-1-Phenyl-1-(5-Phenyl-1,3,4-Oxadiazol-2-yl)methanamine derivatives via in-Situ generation of densely functionalized iminophosphoranes

چکیده مقاله

A novel isocyanide-based four-component reaction between (N-isocyanimino) triphenylphosphorane, benzyl amine, benzaldehyde derivatives, and various carboxylic acids efficiently provides N-benzyl-1-phenyl-1-(5-phenyl-1,3,4- oxadiazol-2-yl)methanamine derivatives in good yields without using any catalyst or activation. The reaction can be carried out as a simple one-pot protocol at room temperature. [Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements for the following free supplemental resource: NMR Spectra for 5i.] Copyright © Taylor and Francis Group, LLC.