Four-component synthesis of 2-(N,N-dialkylamino)-2,4,6-cycloheptatrien-1- one derivatives from tropolone, an isocyanide, a primary amine and an aldehyde via ugi-smiles coupling reaction

چکیده مقاله

The use of Smiles rearrangement in Ugi-type couplings with tropolone allows very straightforward multicomponent formation of 2-(N,N-dialkylamino)-2,4,6- cycloheptatrien-1-one derivatives. The Ugi four-component reaction of isocyanides with tropolone (2-hydroxy-2,4,6-cycloheptatrien-1-one), primary amines and aldehydes proceeds smoothly and cleanly under mild conditions to afford 2-(N,N-dialkylamino)-2,4,6-cycloheptatrien- 1-one derivatives in fairly good yields.