N-isocyaniminotriphenylphosphorane (Ph3PNNC) as an efficient reagent for the synthesis of fully substituted 1,3,4-oxadiazoles from 3-phenyl-2-propynoic acid, secondary amines and aromatic bis-aldehydes

چکیده مقاله

Reactions of N-isocyaniminotriphenylphosphorane (Ph₃PNNC) with aromatic bis-aldehydes (isophthalaldehyde and terphthalaldehyde) in the presence of 3-phenyl-2-propynoic acid and secondary amines proceed smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions and no side reactions were observed. © 2013 Taylor & Francis Group, LLC.